Modern protein became non-functional when scientists reversed changes
"In a kind of evolutionary bridge-burning, once a gene has morphed into its current state, the road back gets blocked, new research suggests. So there's no easy way to turn back.
...Their results, detailed in the Sept. 24 issue of the journal Nature, reveal that over long time scales, certain genetic blockades arise that make it nearly impossible to transform a modern protein into its ancestral state, even if ancient environmental pressures were to exist.
"This is the best demonstration of the molecular foundations of evolutionary irreversibility that I have ever read," said Michael Rose, a professor of ecology and evolutionary biology at the University of California, Irvine, who was not involved in the current study."
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